ZDHHC6

Across TCGA patient cohorts, ZDHHC6 mutation is significantly associated with the RNA expression of many other genes, with 2,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC6-associated genes across cancer lineages are NDUFB9P1, RNA5SP467, and SOCS5P5. Each is linked with ZDHHC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC6-to-partner and partner-to-ZDHHC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFB9P1 grouped by ZDHHC6-low versus ZDHHC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC6→partner) and Y-score (partner→ZDHHC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFB9P1 →	+0.180	+1.696	.001	.007	3	2
CESC	RNA5SP467 →	+0.313	+5.539	<.001	.004	3	2
CESC	SOCS5P5 →	+0.041	+5.812	<.001	.003	3	2
UCEC	MIR3912 →	+0.285	+2.316	<.001	.002	3	2
CESC	CDRT15P7 →	+0.072	+5.669	<.001	.003	3	2
SKCM	OR4K11P →	+0.023	+5.163	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,451 associations by consensus.

NDUFB9P1 by ZDHHC6 expression — UCEC

Explore this box plot interactively →