ZDHHC6

Across TCGA patient cohorts, ZDHHC6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC6-associated genes across cancer lineages are Ku80, MEK1, and p27_pT198. Each is linked with ZDHHC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC6-to-partner and partner-to-ZDHHC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZDHHC6-low versus ZDHHC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC6→partner) and Y-score (partner→ZDHHC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.259	+2.013	.015	.018	3	1
UCEC	MEK1 →	+0.495	+3.584	.002	.002	3	1
UCEC	p27_pT198 →	+0.115	+2.700	.016	.006	3	1
UCEC	PDCD4 →	-0.619	-2.000	.003	.032	3	1
UCEC	STAT3_pY705 →	-0.414	-3.311	<.001	.010	3	1
UCEC	ASNS →	+0.564	+2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by ZDHHC6 expression — UCEC

Explore this box plot interactively →