ZDHHC5

Across TCGA patient cohorts, ZDHHC5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC5-associated genes across cancer lineages are p27_pT157, Rad50, and ATM. Each is linked with ZDHHC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC5-to-partner and partner-to-ZDHHC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by ZDHHC5-low versus ZDHHC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC5→partner) and Y-score (partner→ZDHHC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT157 →	-0.045	-1.794	.010	.024	3	2
UCEC	Rad50 →	-0.178	-1.064	.016	.048	3	2
UCEC	ATM →	-0.409	-2.794	.003	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.984	+2.536	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.074	-1.780	.015	.024	3	1
UCEC	EGFR_pY1068 →	-0.176	-1.847	.022	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p27_pT157 by ZDHHC5 expression — UCEC

Explore this box plot interactively →