ZDHHC5

Across TCGA cell cohorts, ZDHHC5 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZDHHC5-associated genes across cancer lineages are MYOD1, TKTL2, and TRIM36. Each is linked with ZDHHC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC5-to-partner and partner-to-ZDHHC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by ZDHHC5-low versus ZDHHC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC5→partner) and Y-score (partner→ZDHHC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYOD1 →	+0.009	+2.514	<.001	.007	3	1
LARGE_INTESTINE	TKTL2 →	+0.049	+3.772	<.001	<.001	3	1
LARGE_INTESTINE	TRIM36 →	+1.251	+3.299	<.001	.004	3	1
LARGE_INTESTINE	NR4A2 →	+0.974	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CEACAM3 →	+0.543	+3.710	<.001	.001	3	1
LARGE_INTESTINE	SMIM10L2A →	+0.558	+3.421	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

MYOD1 by ZDHHC5 expression — LARGE_INTESTINE

Explore this box plot interactively →