ZDHHC4

Across TCGA patient cohorts, ZDHHC4 mutation is significantly associated with the RNA expression of many other genes, with 406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC4-associated genes across cancer lineages are LINC01810, EMID1, and DEFB135. Each is linked with ZDHHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC4-to-partner and partner-to-ZDHHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01810 grouped by ZDHHC4-low versus ZDHHC4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC4→partner) and Y-score (partner→ZDHHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC01810 →	+0.109	+7.640	<.001	.009	3	2
UCEC	EMID1 →	-1.726	-2.796	<.001	.003	3	2
SKCM	DEFB135 →	+0.232	+2.589	<.001	.002	3	2
SKCM	RPSAP72 →	+0.197	+2.562	.007	.006	3	2
SKCM	SRIP2 →	+0.150	+3.680	<.001	<.001	3	2
UCEC	MMEL1 →	-0.758	-2.807	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 406 associations by consensus.

LINC01810 by ZDHHC4 expression — BLCA

Explore this box plot interactively →