ZDHHC4

Across TCGA patient cohorts, ZDHHC4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC4-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and MSH2. Each is linked with ZDHHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC4-to-partner and partner-to-ZDHHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZDHHC4-low versus ZDHHC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC4→partner) and Y-score (partner→ZDHHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.150	-3.295	.001	.009	3	1
UCEC	A-Raf_pS299 →	-0.128	-3.169	.021	.019	3	1
UCEC	MSH2 →	-0.330	-2.312	.002	.034	3	1
UCEC	N-Ras →	-0.141	-2.571	.010	.011	3	1
UCEC	p70-S6K_pT389 →	-0.224	-2.584	.011	.011	3	1
UCEC	PRAS40_pT246 →	+0.201	+2.598	.011	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by ZDHHC4 expression — UCEC

Explore this box plot interactively →