ZDHHC4

Across TCGA cell cohorts, ZDHHC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,990 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZDHHC4-associated GO terms across cancer lineages are Meiotic mismatch repair, Meiotic telomere tethering at nuclear periphery, and Meiotic telomere clustering. Each is linked with ZDHHC4 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZDHHC4-to-partner and partner-to-ZDHHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic mismatch repair grouped by ZDHHC4-low versus ZDHHC4-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC4→partner) and Y-score (partner→ZDHHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Meiotic mismatch repair →	+0.120	+0.875	<.001	<.001	3	15
BLOOD_Myeloma	Meiotic telomere tethering at nuclear periphery →	+0.152	+1.114	.001	.002	3	11
BLOOD_Myeloma	Meiotic telomere clustering →	+0.152	+1.114	.001	.002	3	11
BLOOD_Myeloma	Meiotic attachment of telomere to nuclear envelope →	+0.152	+1.114	.001	.002	3	11
BONE	Electron transport chain →	+0.069	+0.823	.008	.004	3	11
KIDNEY	Regulation of myoblast fusion →	+0.114	+1.918	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,990 associations by consensus.

Meiotic mismatch repair by ZDHHC4 expression — LUNG_NSCLC_LUAD

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