ZDHHC4

Across TCGA cell cohorts, ZDHHC4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ZDHHC4-associated genes across cancer lineages are ITGAD, ACSM6, and C12orf40. Each is linked with ZDHHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC4-to-partner and partner-to-ZDHHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by ZDHHC4-low versus ZDHHC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC4→partner) and Y-score (partner→ZDHHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.014	+4.510	<.001	.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
SKIN	MS4A6E →	+0.072	+5.415	<.001	.004	3	1
SKIN	OOSP4B →	+0.075	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ITGAD by ZDHHC4 expression — LARGE_INTESTINE

Explore this box plot interactively →