ZDHHC24

Across TCGA pan-cancer cohorts, ZDHHC24 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZDHHC24 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZDHHC24 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZDHHC24 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD, UCEC, and SKCM are the cancer types where ZDHHC24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.159	0.785	.003	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	1.000	0.197	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZDHHC24–COAD (OS)

Open the COAD breakdown →