ZDHHC24

Across TCGA pan-cancer cohorts, ZDHHC24 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZDHHC24 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZDHHC24 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZDHHC24 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where ZDHHC24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.812	0.407	.001	16	view →
LUAD	DFS	Median	II,III,IV	0.741	1.000	.006	7	view →
LSCC	DFS	Median	All	0.537	0.860	.019	6	view →
CCRCC	DFS	Quartile	All	0.394	1.000	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZDHHC24–HNSC (DFS)

Open the HNSC breakdown →