Across TCGA pan-cancer cohorts, ZDHHC23 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZDHHC23 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher ZDHHC23 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZDHHC23 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.
UVM, SCLC, and STAD are the cancer types where ZDHHC23 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.