ZDHHC22

Across TCGA patient cohorts, ZDHHC22 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC22-associated genes across cancer lineages are Notch1, EGFR_pY1068, and A-Raf_pS299. Each is linked with ZDHHC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC22-to-partner and partner-to-ZDHHC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZDHHC22-low versus ZDHHC22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC22→partner) and Y-score (partner→ZDHHC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.178	+3.183	.005	.009	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.700	.041	.006	3	1
UCEC	A-Raf_pS299 →	-0.117	-3.000	.030	.036	3	1
UCEC	FoxM1 →	+0.334	+3.807	.004	<.001	3	1
UCEC	Smad1 →	+0.162	+2.700	.022	.006	3	1
UCEC	STAT3_pY705 →	-0.492	-2.000	<.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by ZDHHC22 expression — UCEC

Explore this box plot interactively →