ZDHHC22

Across TCGA cell cohorts, ZDHHC22 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,950 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZDHHC22-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of DNA metabolic process, and Regulation of DNA repair. Each is linked with ZDHHC22 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZDHHC22-to-partner and partner-to-ZDHHC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by ZDHHC22-low versus ZDHHC22-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC22→partner) and Y-score (partner→ZDHHC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of DNA repair →	+0.065	+0.832	<.001	<.001	3	9
SOFT_TISSUE	Positive regulation of DNA metabolic process →	+0.046	+0.898	<.001	<.001	3	6
SOFT_TISSUE	Regulation of DNA repair →	+0.096	+1.408	<.001	<.001	3	6
SOFT_TISSUE	Granzyme-mediated apoptotic signaling pathway →	+0.125	+1.355	<.001	<.001	3	6
SOFT_TISSUE	Positive regulation of sodium ion transport →	-0.167	-1.089	<.001	.002	3	6
LUNG_SCLC	Digestion →	-0.137	-2.493	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,950 associations by consensus.

Positive regulation of DNA repair by ZDHHC22 expression — SOFT_TISSUE

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