ZDHHC20

Across TCGA pan-cancer cohorts, ZDHHC20 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZDHHC20 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZDHHC20 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZDHHC20 expression acts as an unfavorable survival marker.

LSCC, HNSC, and PDAC are the cancer types where ZDHHC20 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.595	0.913	.001	16	view →
HNSC	DFS	Median	All	0.698	1.000	.020	8	view →
PDAC	OS	Tertile	IV	0.540	0.973	.038	6	view →
UCEC	DFS	Tertile	III,IV	0.527	1.000	.049	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZDHHC20–LSCC (DFS)

Open the LSCC breakdown →