ZDHHC20

Across TCGA patient cohorts, ZDHHC20 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC20-associated genes across cancer lineages are Di-Ras3, MEK1, and MSH6. Each is linked with ZDHHC20 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC20-to-partner and partner-to-ZDHHC20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by ZDHHC20-low versus ZDHHC20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC20→partner) and Y-score (partner→ZDHHC20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.192	-3.156	.007	.018	3	2
UCEC	MEK1 →	+0.418	+2.321	.018	.034	3	1
UCEC	MSH6 →	-0.404	-3.159	.011	.019	3	1
UCEC	p62 Lck ligand →	+0.371	+3.179	.018	.010	3	1
UCEC	MSH2 →	-0.384	-3.312	<.001	.010	2	1
UCEC	XRCC1 →	-0.203	-3.321	.007	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Di-Ras3 by ZDHHC20 expression — UCEC

Explore this box plot interactively →