ZDHHC2

Across TCGA patient cohorts, ZDHHC2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC2-associated genes across cancer lineages are Bax, Caspase-8, and IGFBP2. Each is linked with ZDHHC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC2-to-partner and partner-to-ZDHHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by ZDHHC2-low versus ZDHHC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC2→partner) and Y-score (partner→ZDHHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.258	+3.321	.007	.009	3	2
UCEC	Caspase-8 →	-0.245	-1.906	.015	.016	3	2
UCEC	IGFBP2 →	-0.710	-2.321	.006	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-3.700	.001	.001	3	1
UCEC	MSH2 →	-0.291	-1.990	.001	.030	3	1
UCEC	mTOR_pS2448 →	-0.161	-2.680	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Bax by ZDHHC2 expression — UCEC

Explore this box plot interactively →