ZDHHC19

Across TCGA patient cohorts, ZDHHC19 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC19-associated genes across cancer lineages are eIF4G, ERK2, and Ku80. Each is linked with ZDHHC19 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC19-to-partner and partner-to-ZDHHC19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by ZDHHC19-low versus ZDHHC19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC19→partner) and Y-score (partner→ZDHHC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.370	+2.999	.010	.035	3	1
UCEC	ERK2 →	+0.245	+3.321	.006	.009	3	1
UCEC	Ku80 →	+0.260	+1.887	.018	.031	3	1
UCEC	MAPK_pT202_Y204 →	-0.535	-3.169	.014	.019	3	1
UCEC	MEK1 →	+0.472	+3.169	.005	.019	3	1
UCEC	p62 Lck ligand →	+0.523	+2.469	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4G by ZDHHC19 expression — UCEC

Explore this box plot interactively →