Across TCGA patient cohorts, ZDHHC18 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC18-associated genes across cancer lineages are eIF4E, Ku80, and MEK1. Each is linked with ZDHHC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC18-to-partner and partner-to-ZDHHC18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC18→partner) and Y-score (partner→ZDHHC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.185	+3.335	.029	.005	3	1
UCEC	Ku80 →	+0.303	+1.884	.001	.030	3	1
UCEC	MEK1 →	+0.348	+2.584	.018	.010	3	1
UCEC	mTOR_pS2448 →	-0.120	-2.095	.044	.017	3	1
UCEC	Notch1 →	+0.163	+2.009	.003	.017	3	1
UCEC	p27_pT198 →	+0.102	+2.584	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ZDHHC18 survival (RNA) · tumor vs normal (RNA) · all ZDHHC18 data types