ZDHHC16

Across TCGA patient cohorts, ZDHHC16 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC16-associated genes across cancer lineages are MSH2, Caspase-7-cleavedD198, and FASN. Each is linked with ZDHHC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC16-to-partner and partner-to-ZDHHC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ZDHHC16-low versus ZDHHC16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC16→partner) and Y-score (partner→ZDHHC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.315	-2.990	.002	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.727	+2.341	.006	.019	3	2
UCEC	FASN →	+0.458	+2.000	.009	.032	2	2
UCEC	FOXO3a_pS318_S321 →	-0.136	-3.459	.015	.005	3	1
UCEC	GAPDH →	+0.482	+2.321	.046	.033	3	1
UCEC	ACC1 →	+0.509	+3.183	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MSH2 by ZDHHC16 expression — UCEC

Explore this box plot interactively →