ZDHHC14

Across TCGA patient cohorts, ZDHHC14 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC14-associated genes across cancer lineages are EGFR_pY1068, TFRC, and PCNA. Each is linked with ZDHHC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC14-to-partner and partner-to-ZDHHC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZDHHC14-low versus ZDHHC14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC14→partner) and Y-score (partner→ZDHHC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EGFR_pY1068 →	+1.196	+2.816	<.001	.036	3	2
SKCM	TFRC →	+0.771	+3.000	.015	.036	3	2
UCEC	PCNA →	+0.319	+3.807	.001	<.001	3	2
LUSC	EGFR →	+0.904	+2.816	<.001	.036	3	1
LUSC	ER-alpha_pS118 →	+0.110	+2.853	.043	.034	3	1
UCEC	FoxM1 →	+0.322	+2.700	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

EGFR_pY1068 by ZDHHC14 expression — LUSC

Explore this box plot interactively →