ZDHHC14

Across TCGA cell cohorts, ZDHHC14 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZDHHC14-associated genes across cancer lineages are SLC38A8, KSR2, and LRIT2. Each is linked with ZDHHC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC14-to-partner and partner-to-ZDHHC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC38A8 grouped by ZDHHC14-low versus ZDHHC14-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC14→partner) and Y-score (partner→ZDHHC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC38A8 →	+0.054	+4.606	.004	.001	3	2
BLOOD_Leukemia	KSR2 →	+0.455	+3.798	<.001	.004	3	2
LUNG_NSCLC_LUAD	LRIT2 →	+0.022	+4.887	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.311	+3.212	.001	.006	3	1
LARGE_INTESTINE	FMO1 →	+0.088	+2.777	.001	.002	3	1
LARGE_INTESTINE	RFX4 →	+0.028	+3.621	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

SLC38A8 by ZDHHC14 expression — BLOOD_Lymphoma

Explore this box plot interactively →