ZDHHC13

Across TCGA pan-cancer cohorts, ZDHHC13 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZDHHC13 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZDHHC13 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZDHHC13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and PDAC are the cancer types where ZDHHC13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.771	0.551	.010	32	view →
COAD	DFS	Median	All	1.000	0.895	.033	12	view →
PDAC	OS	Tertile	IV	0.395	0.973	.024	6	view →
LUAD	DFS	Tertile	III,IV	0.983	0.643	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZDHHC13–HNSC (DFS)

Open the HNSC breakdown →