ZDHHC12

Across TCGA pan-cancer cohorts, ZDHHC12 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZDHHC12 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZDHHC12 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZDHHC12 expression acts as an unfavorable survival marker.

HNSC and STAD are the cancer types where ZDHHC12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.176	0.685	.024	30	view →
STAD	OS	Median	All	0.161	0.583	.010	21	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ZDHHC12–HNSC (OS)

Open the HNSC breakdown →