ZDHHC12

Across TCGA patient cohorts, ZDHHC12 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC12-associated genes across cancer lineages are Ku80, MAPK_pT202_Y204, and Notch1. Each is linked with ZDHHC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC12-to-partner and partner-to-ZDHHC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZDHHC12-low versus ZDHHC12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC12→partner) and Y-score (partner→ZDHHC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.383	+3.183	.003	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.637	-3.000	.013	.036	3	1
UCEC	Notch1 →	+0.280	+3.009	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.360	+3.009	.044	.019	3	1
UCEC	STAT3_pY705 →	-0.376	-3.169	.008	.020	3	1
UCEC	AR →	-0.528	-3.169	.009	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by ZDHHC12 expression — UCEC

Explore this box plot interactively →