Across TCGA patient cohorts, ZDHHC11 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC11-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and FOXO3a_pS318_S321. Each is linked with ZDHHC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC11-to-partner and partner-to-ZDHHC11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC11→partner) and Y-score (partner→ZDHHC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.296	-3.700	.004	.001	3	1
UCEC	eIF4G →	+0.326	+3.169	.011	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.162	-2.906	.001	.001	3	1
UCEC	Gab2 →	+0.324	+1.807	.028	.027	3	1
UCEC	GAPDH →	+0.466	+2.999	.035	.035	3	1
UCEC	ACC1 →	+0.298	+2.820	.047	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

ZDHHC11 survival (RNA) · tumor vs normal (RNA) · all ZDHHC11 data types