ZDHHC1

Across TCGA patient cohorts, ZDHHC1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC1-associated genes across cancer lineages are PCNA, 4E-BP1_pS65, and EGFR_pY1068. Each is linked with ZDHHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC1-to-partner and partner-to-ZDHHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZDHHC1-low versus ZDHHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC1→partner) and Y-score (partner→ZDHHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.233	+2.584	.013	.010	3	2
UCEC	4E-BP1_pS65 →	-0.213	-2.794	.012	.003	3	2
UCEC	EGFR_pY1068 →	-0.325	-2.807	.002	.003	3	1
UCEC	ERK2 →	+0.191	+3.169	.023	.019	3	1
UCEC	FASN →	+0.392	+2.321	.022	.034	3	1
UCEC	ACC1 →	+0.400	+2.807	.011	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PCNA by ZDHHC1 expression — UCEC

Explore this box plot interactively →