ZDHHC1

Across TCGA cell cohorts, ZDHHC1 mutation is significantly associated with the mutation status of many other genes, with 1,277 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZDHHC1-associated genes across cancer lineages are VAV2, REPIN1, and PES1. Each is linked with ZDHHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC1-to-partner and partner-to-ZDHHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAV2 grouped by ZDHHC1-low versus ZDHHC1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC1→partner) and Y-score (partner→ZDHHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VAV2 →	+4.044	+5.000	.008	.008	1	2
CNS	REPIN1 →	+6.044	+6.044	.001	.001	1	2
LARGE_INTESTINE	PES1 →	+3.459	+3.459	.006	.006	1	2
BLOOD_Leukemia	CARD10 →	+3.145	+3.932	.004	.004	1	2
LARGE_INTESTINE	RANGAP1 →	+4.459	+4.459	<.001	<.001	1	2
LARGE_INTESTINE	TCFL5 →	+3.459	+3.459	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,277 associations by consensus.

VAV2 by ZDHHC1 expression — CNS

Explore this box plot interactively →