Across TCGA patient cohorts, ZCWPW2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCWPW2-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and FASN. Each is linked with ZCWPW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCWPW2-to-partner and partner-to-ZCWPW2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCWPW2→partner) and Y-score (partner→ZCWPW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.245	+3.000	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.308	-3.321	.011	.010	3	1
UCEC	FASN →	+0.633	+2.459	<.001	.020	3	1
UCEC	MEK1 →	+0.360	+3.169	.041	.019	3	1
UCEC	p62 Lck ligand →	+0.322	+2.817	.041	.036	3	1
UCEC	STAT3_pY705 →	-0.375	-3.311	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

ZCWPW2 survival (RNA) · tumor vs normal (RNA) · all ZCWPW2 data types