ZCWPW1

Across TCGA pan-cancer cohorts, ZCWPW1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZCWPW1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ZCWPW1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZCWPW1 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

GBM, UCEC, and LSCC are the cancer types where ZCWPW1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.476	0.231	.001	27	view →
UCEC	DFS	Tertile	II,III,IV	0.872	0.337	.019	12	view →
LSCC	DFS	Quartile	II,III,IV	0.996	0.509	.017	8	view →
HNSC	DFS	Quartile	III,IV	1.000	0.533	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZCWPW1–GBM (DFS)

Open the GBM breakdown →