ZCWPW1

Across TCGA patient cohorts, ZCWPW1 mutation is significantly associated with the RNA expression of many other genes, with 1,720 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCWPW1-associated genes across cancer lineages are RPA3P1, RNA5-8SP5, and RNU6-13P. Each is linked with ZCWPW1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZCWPW1-to-partner and partner-to-ZCWPW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPA3P1 grouped by ZCWPW1-low versus ZCWPW1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCWPW1→partner) and Y-score (partner→ZCWPW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPA3P1 →	+0.152	+4.716	<.001	.003	3	3
HNSC	RNA5-8SP5 →	+0.269	+5.008	<.001	.004	3	3
UCEC	RNU6-13P →	+0.191	+2.022	.007	.003	3	3
BRCA	RNU6-275P →	+0.326	+4.431	<.001	.008	3	2
STAD	RNA5SP325 →	+0.440	+3.878	.006	.008	3	2
LUSC	RPL17P19 →	+0.112	+4.548	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,720 associations by consensus.

RPA3P1 by ZCWPW1 expression — HNSC

Explore this box plot interactively →