ZCWPW1

Across TCGA cell cohorts, ZCWPW1 mutation is significantly associated with the mutation status of many other genes, with 5,563 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCWPW1-associated genes across cancer lineages are TP53BP1, DLG5, and ENTPD2. Each is linked with ZCWPW1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZCWPW1-to-partner and partner-to-ZCWPW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53BP1 grouped by ZCWPW1-low versus ZCWPW1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCWPW1→partner) and Y-score (partner→ZCWPW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TP53BP1 →	+2.478	+4.392	<.001	<.001	1	5
STOMACH	DLG5 →	+3.942	+4.584	.002	.002	1	4
SKIN	ENTPD2 →	+5.392	+4.824	.004	.004	1	4
LARGE_INTESTINE	PIK3C2A →	+2.215	+3.247	.003	.003	1	4
UPPER_AERODIGESTIVE_TRACT	CFTR →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	LAMA3 →	+1.799	+3.769	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,563 associations by consensus.

TP53BP1 by ZCWPW1 expression — LARGE_INTESTINE

Explore this box plot interactively →