ZCRB1

Across TCGA pan-cancer cohorts, ZCRB1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZCRB1 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZCRB1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZCRB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where ZCRB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.981	0.868	.034	12	view →
PDAC	DFS	Tertile	All	0.380	0.663	.005	12	view →
CCRCC	OS	Median	All	0.633	0.972	.016	6	view →
GBM	OS	Quartile	All	0.626	0.439	.012	2	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.878	.037	1	view →
LUAD	OS	Median	All	0.978	0.787	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZCRB1–UCEC (OS)

Open the UCEC breakdown →