ZCCHC9

Across TCGA patient cohorts, ZCCHC9 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC9-associated genes across cancer lineages are FoxM1, MIG-6, and Notch1. Each is linked with ZCCHC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC9-to-partner and partner-to-ZCCHC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ZCCHC9-low versus ZCCHC9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC9→partner) and Y-score (partner→ZCCHC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.266	+2.321	.040	.035	3	1
UCEC	MIG-6 →	+0.110	+2.999	.027	.035	3	1
UCEC	Notch1 →	+0.183	+2.321	.009	.035	3	1
UCEC	p38-MAPK →	-0.168	-2.321	.042	.035	3	1
UCEC	PDCD4 →	-0.613	-2.990	.009	.036	3	1
UCEC	YB-1 →	+0.165	+2.348	.038	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by ZCCHC9 expression — UCEC

Explore this box plot interactively →