ZCCHC8

Across TCGA pan-cancer cohorts, ZCCHC8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZCCHC8 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZCCHC8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZCCHC8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where ZCCHC8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.999	0.880	<.001	61	view →
HNSC	DFS	Quartile	All	0.670	0.911	.002	14	view →
LUAD	OS	Tertile	III,IV	1.000	0.384	.019	9	view →
GBM	OS	Median	All	0.469	0.301	.034	3	view →
CCRCC	DFS	Median	IV	0.749	0.253	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZCCHC8–LSCC (DFS)

Open the LSCC breakdown →