ZCCHC7

Across TCGA pan-cancer cohorts, ZCCHC7 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZCCHC7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZCCHC7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZCCHC7 is over-expressed in tumor.

COAD, CCRCC, and LSCC are the cancer types where ZCCHC7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZCCHC7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.416	.006	7	view →
CCRCC	Male	II,III,IV	+0.377	<.001	6	view →
LSCC	Male	II,III,IV	+0.374	<.001	4	view →
LUAD	All	All	+0.177	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZCCHC7–COAD

Open the COAD breakdown →