ZCCHC7

Across TCGA patient cohorts, ZCCHC7 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC7-associated genes across cancer lineages are p62 Lck ligand, C-Raf, and FoxM1. Each is linked with ZCCHC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC7-to-partner and partner-to-ZCCHC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZCCHC7-low versus ZCCHC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC7→partner) and Y-score (partner→ZCCHC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.275	+2.584	.014	.010	3	2
UCEC	C-Raf →	+0.159	+2.000	.001	.009	3	2
UCEC	FoxM1 →	+0.188	+2.232	.036	.005	3	1
UCEC	IGFBP2 →	-0.502	-1.440	.025	.024	3	1
UCEC	Ku80 →	+0.209	+1.183	.010	.044	3	1
UCEC	p90 RSK →	+0.137	+1.817	.039	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p62 Lck ligand by ZCCHC7 expression — UCEC

Explore this box plot interactively →