ZCCHC7

Across TCGA cell cohorts, ZCCHC7 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible ZCCHC7-associated genes across cancer lineages are ADGRL4, OR4F21, and TMEM31. Each is linked with ZCCHC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC7-to-partner and partner-to-ZCCHC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRL4 grouped by ZCCHC7-low versus ZCCHC7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC7→partner) and Y-score (partner→ZCCHC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADGRL4 →	+0.059	+3.569	.001	.006	3	1
LARGE_INTESTINE	OR4F21 →	+0.142	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	TMEM31 →	+0.507	+3.263	<.001	.008	3	1
STOMACH	ACOD1 →	+0.005	+4.285	<.001	.007	3	1
STOMACH	AHSP →	+0.312	+4.432	<.001	.003	3	1
STOMACH	MBD3L2B →	+0.042	+4.432	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ADGRL4 by ZCCHC7 expression — LARGE_INTESTINE

Explore this box plot interactively →