ZCCHC4

Across TCGA patient cohorts, ZCCHC4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC4-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with ZCCHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC4-to-partner and partner-to-ZCCHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZCCHC4-low versus ZCCHC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC4→partner) and Y-score (partner→ZCCHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.238	-1.807	.021	.027	3	1
UCEC	A-Raf_pS299 →	-0.104	-3.169	.034	.019	3	1
UCEC	ERK2 →	+0.226	+2.321	.004	.006	3	1
UCEC	MEK1 →	+0.304	+2.459	.044	.019	3	1
UCEC	Shc_pY317 →	-0.245	-2.321	<.001	.006	3	1
UCEC	Smad4 →	-0.101	-3.169	.042	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by ZCCHC4 expression — UCEC

Explore this box plot interactively →