ZCCHC4

Across TCGA cell cohorts, ZCCHC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,119 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZCCHC4-associated GO terms across cancer lineages are Centriole replication, Positive regulation of organelle assembly, and Anaphase-promoting complex-dependent catabolic process. Each is linked with ZCCHC4 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZCCHC4-to-partner and partner-to-ZCCHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centriole replication grouped by ZCCHC4-low versus ZCCHC4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC4→partner) and Y-score (partner→ZCCHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Centriole replication →	+0.122	+0.584	<.001	<.001	3	15
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.064	+0.750	.002	.004	3	14
LIVER	Anaphase-promoting complex-dependent catabolic process →	+0.108	+0.759	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.088	+0.769	.001	.005	3	14
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.073	+0.750	.001	.001	3	13
LARGE_INTESTINE	Protein K11-linked ubiquitination →	+0.078	+0.554	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,119 associations by consensus.

Centriole replication by ZCCHC4 expression — SOFT_TISSUE

Explore this box plot interactively →