ZCCHC4

Across TCGA cell cohorts, ZCCHC4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZCCHC4-associated genes across cancer lineages are FAM205A, RBMXL2, and BPIFB3. Each is linked with ZCCHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC4-to-partner and partner-to-ZCCHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by ZCCHC4-low versus ZCCHC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC4→partner) and Y-score (partner→ZCCHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1
SKIN	RBMXL2 →	+0.018	+4.459	.001	.001	3	1
SKIN	BPIFB3 →	+0.018	+4.437	<.001	.004	3	1
SKIN	TDRD1 →	+1.018	+3.793	<.001	.007	3	1
BLOOD_Leukemia	KIR3DL1 →	+0.028	+4.276	.001	.007	3	1
BLOOD_Leukemia	USP17L13 →	+0.004	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FAM205A by ZCCHC4 expression — LARGE_INTESTINE

Explore this box plot interactively →