ZCCHC3

Across TCGA pan-cancer cohorts, ZCCHC3 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZCCHC3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ZCCHC3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZCCHC3 is over-expressed in tumor, although a few such as CCRCC and OV show the opposite, repressed pattern.

CCRCC, LSCC, and COAD are the cancer types where ZCCHC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZCCHC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	II,III,IV	−0.353	<.001	11	view →
LSCC	Male	All	+0.742	<.001	8	view →
COAD	All	III,IV	+0.339	.001	7	view →
HNSC	All	All	+0.238	.013	4	view →
OV	All	All	−0.491	.008	2	view →
PDAC	Male	III,IV	−0.362	.033	1	view →
LUAD	Female	II,III,IV	−0.215	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZCCHC3–CCRCC

Open the CCRCC breakdown →