ZCCHC3

Across TCGA patient cohorts, ZCCHC3 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC3-associated genes across cancer lineages are SNORD126, RNA5SP442, and IGHVII-22-1. Each is linked with ZCCHC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC3-to-partner and partner-to-ZCCHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD126 grouped by ZCCHC3-low versus ZCCHC3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC3→partner) and Y-score (partner→ZCCHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD126 →	+0.423	+2.878	<.001	.008	3	2
COAD	RNA5SP442 →	+0.561	+4.308	<.001	.009	3	2
BLCA	IGHVII-22-1 →	+0.380	+3.298	<.001	.003	3	1
BLCA	SOD1P3 →	+0.333	+3.185	<.001	.003	3	1
BLCA	IGLVIV-59 →	+0.329	+3.592	<.001	.004	3	1
BLCA	RN7SL847P →	+0.161	+3.214	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

SNORD126 by ZCCHC3 expression — BLCA

Explore this box plot interactively →