ZCCHC3

Across TCGA cell cohorts, ZCCHC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,464 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZCCHC3-associated GO terms across cancer lineages are Positive regulation of RIG-I signaling pathway, Negative regulation of meiotic cell cycle phase transition, and Copper ion export. Each is linked with ZCCHC3 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZCCHC3-to-partner and partner-to-ZCCHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of RIG-I signaling pathway grouped by ZCCHC3-low versus ZCCHC3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC3→partner) and Y-score (partner→ZCCHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of RIG-I signaling pathway →	+0.155	+0.860	.001	.002	2	15
LUNG_NSCLC_LUAD	Negative regulation of meiotic cell cycle phase transition →	+0.095	+0.749	<.001	<.001	3	14
OVARY	Copper ion export →	-0.166	-0.796	.003	.001	3	13
LIVER	Regulation of RIG-I signaling pathway →	+0.122	+1.041	<.001	<.001	3	12
OESOPHAGUS	Regulation of protein localization to endoplasmic reticulum →	+0.169	+1.070	<.001	<.001	3	12
OESOPHAGUS	Positive regulation of protein localization to endoplasmic reticulum →	+0.164	+1.026	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,464 associations by consensus.

Positive regulation of RIG-I signaling pathway by ZCCHC3 expression — BONE

Explore this box plot interactively →