ZCCHC24

Across TCGA pan-cancer cohorts, ZCCHC24 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZCCHC24 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZCCHC24 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZCCHC24 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where ZCCHC24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.240	1.000	.014	20	view →
LSCC	DFS	Quartile	II,III,IV	0.455	0.848	.008	9	view →
LUAD	DFS	Median	All	0.724	0.517	.025	3	view →
CCRCC	DFS	Tertile	All	0.593	0.803	.036	3	view →
PDAC	DFS	Median	III,IV	0.686	0.341	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZCCHC24–UCEC (DFS)

Open the UCEC breakdown →