ZCCHC2

Across TCGA patient cohorts, ZCCHC2 mutation is significantly associated with the RNA expression of many other genes, with 4,274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC2-associated genes across cancer lineages are PIAS2, RPL21P88, and TRMU. Each is linked with ZCCHC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZCCHC2-to-partner and partner-to-ZCCHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIAS2 grouped by ZCCHC2-low versus ZCCHC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC2→partner) and Y-score (partner→ZCCHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIAS2 →	+0.401	+3.021	<.001	<.001	3	4
LUAD	RPL21P88 →	+0.118	+4.293	.004	.008	3	3
UCEC	TRMU →	+0.616	+2.099	<.001	<.001	3	3
UCEC	BAG1 →	+0.540	+1.857	<.001	<.001	3	3
UCEC	GOT1 →	+0.334	+2.163	.002	<.001	3	3
LIHC	OR13H1 →	+0.016	+4.091	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,274 associations by consensus.

PIAS2 by ZCCHC2 expression — UCEC

Explore this box plot interactively →