ZCCHC2

Across TCGA cell cohorts, ZCCHC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC2-associated GO terms across cancer lineages are Copper ion export, Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway, and Positive regulation of intracellular estrogen receptor signaling pathway. Each is linked with ZCCHC2 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZCCHC2-to-partner and partner-to-ZCCHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by ZCCHC2-low versus ZCCHC2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC2→partner) and Y-score (partner→ZCCHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Copper ion export →	-0.194	-0.911	<.001	<.001	3	10
SOFT_TISSUE	Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway →	+0.152	+0.889	<.001	<.001	3	10
BLOOD_Leukemia	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.080	+0.714	.001	<.001	3	9
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.202	+0.924	<.001	<.001	3	9
LARGE_INTESTINE	Subtelomeric heterochromatin formation →	+0.063	+0.623	.001	.002	3	9
LARGE_INTESTINE	Host-mediated activation of viral transcription →	+0.107	+0.792	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,344 associations by consensus.

Copper ion export by ZCCHC2 expression — OVARY

Explore this box plot interactively →