ZCCHC17

Across TCGA patient cohorts, ZCCHC17 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC17-associated genes across cancer lineages are EGFR_pY1173, eIF4E, and FOXO3a_pS318_S321. Each is linked with ZCCHC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC17-to-partner and partner-to-ZCCHC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by ZCCHC17-low versus ZCCHC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC17→partner) and Y-score (partner→ZCCHC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.088	+2.196	.036	.034	3	1
UCEC	eIF4E →	+0.259	+2.820	.019	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.171	-3.321	.008	.010	3	1
UCEC	Ku80 →	+0.351	+2.183	.004	.035	3	1
UCEC	mTOR_pS2448 →	-0.261	-3.156	<.001	.018	3	1
UCEC	N-Cadherin →	+0.312	+3.009	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1173 by ZCCHC17 expression — UCEC

Explore this box plot interactively →