ZCCHC17

Across TCGA cell cohorts, ZCCHC17 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,030 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZCCHC17-associated GO terms across cancer lineages are mRNA splicing, via endonucleolytic cleavage and ligation, Establishment or maintenance of microtubule cytoskeleton polarity, and Negative regulation of nuclear division. Each is linked with ZCCHC17 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZCCHC17-to-partner and partner-to-ZCCHC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splicing, via endonucleolytic cleavage and ligation grouped by ZCCHC17-low versus ZCCHC17-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC17→partner) and Y-score (partner→ZCCHC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	mRNA splicing, via endonucleolytic cleavage and ligation →	+0.080	+0.601	.007	.005	3	14
LUNG_NSCLC_LUSC	Establishment or maintenance of microtubule cytoskeleton polarity →	+0.239	+0.624	.002	.004	3	12
BLOOD_Leukemia	Negative regulation of nuclear division →	+0.093	+0.492	<.001	<.001	3	12
BREAST	Transport of virus →	+0.184	+0.853	<.001	<.001	3	11
BREAST	Intracellular transport of virus →	+0.184	+0.853	<.001	<.001	3	11
BLOOD_Myeloma	Negative regulation of mitotic cell cycle phase transition →	+0.058	+0.798	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,030 associations by consensus.

mRNA splicing, via endonucleolytic cleavage and ligation by ZCCHC17 expression — LUNG_SCLC

Explore this box plot interactively →