ZCCHC17

Across TCGA cell cohorts, ZCCHC17 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZCCHC17-associated genes across cancer lineages are H2BW2, CBLIF, and CYP11B1. Each is linked with ZCCHC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC17-to-partner and partner-to-ZCCHC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW2 grouped by ZCCHC17-low versus ZCCHC17-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC17→partner) and Y-score (partner→ZCCHC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	H2BW2 →	+0.091	+4.234	<.001	.003	3	1
BLOOD_Leukemia	CBLIF →	+0.081	+3.769	<.001	.008	3	1
BLOOD_Leukemia	CYP11B1 →	+0.072	+4.234	<.001	.003	3	1
BLOOD_Leukemia	OR2D2 →	+0.115	+4.133	<.001	.003	3	1
BLOOD_Leukemia	OR10Q1 →	+0.019	+4.384	<.001	.006	3	1
BLOOD_Leukemia	OR56A3 →	+0.037	+4.060	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

H2BW2 by ZCCHC17 expression — BLOOD_Leukemia

Explore this box plot interactively →