ZCCHC14

Across TCGA patient cohorts, ZCCHC14 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC14-associated genes across cancer lineages are mTOR_pS2448, ATM, and Cyclin-B1. Each is linked with ZCCHC14 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZCCHC14-to-partner and partner-to-ZCCHC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZCCHC14-low versus ZCCHC14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC14→partner) and Y-score (partner→ZCCHC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.101	-1.266	.014	.049	3	3
UCEC	ATM →	-0.592	-1.917	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.612	+1.917	<.001	<.001	3	2
UCEC	ERK2 →	+0.213	+2.459	<.001	<.001	3	2
UCEC	MEK1 →	+0.427	+1.917	<.001	<.001	3	2
UCEC	MSH6 →	-0.319	-1.584	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

mTOR_pS2448 by ZCCHC14 expression — UCEC

Explore this box plot interactively →